Reactive Mesothelial Cells In Pleural Fluid Cytology

The mesothelial cells have central round nuclei with a moderate amount of light purple cytoplasm and a corona or fringe to the cytoplasmic borders.

Reactive mesothelial cells in pleural fluid cytology.

Papanicolaou x100 breast adenocarcinoma cells in pleural effusion. Normally mesotheial cells present only along surface and not in underlying tissue. Hyperplastic mesothelial cells with slightly enlarged nuclei micronucleoli and a clear space or window between adjacent cells present singly and in small clusters. Common cells present in pleural fluid include neutrophils lymphocytes monocytes mesothelial cells and red blood.

The article deals with cytopathology specimens from spaces lined with mesothelium i e. It deals with pericardial fluid peritoneal fluid and pleural fluid. Reactive mesothelial cells reactive mesothelial cells in pleural fluid reactive mesothelial cells are found when there is infection or inflammation present in a body cavity. Numerous mesothelial cells are seen in this pleural fluid from a dog with a transudative effusion with concurrent diapedesis of red blood cells or hemorrhage.

Larger clusters of hyperplastic mesothelial cells showing mildly nuclear atypia with small nucleoli. Reactive pleural effusion showing acute and chronic cells normal mesothelial cells and alveolar macrophages in aggregates and dispersed cells with rounded nuclei and vacuolated cytoplasm. Mesothelial cytopathology is a large part of cytopathology. Atypical mesothelial cell proliferation.

9 14 these studies suggest that 2. Because of the difficulty in distinguishing reactive mh from mm even in tissue specimens such as small pleural biopsies several studies have used immunohistochemical markers to distinguish between reactive and neoplastic mesothelial cells 3 8 or between adenocarcinoma reactive mh and mm in serous effusions. The many faces of reactive mesothelial cells. Bap1 a new marker that is helpful in distinguishing reactive mesothelial cells from malignant mesothelioma.

Neoplastic transformation of mesothelial cells results in malignant mesothelioma an aggressive tumor especially the pleura. Mesothelial cells form conspicuous layer of regularly spaced bland cuboidal cells along pleural surface. Many of the false positives in effusion fluid cytology are caused by the atypical features of reactive mesothelial cells associated with a variety of underlying benign processes including acute pancreatitis 2 tuberculosis 1 ovarian fibroma 1 pulmonary infarction 3 chemotherapy 4 and cirrhosis.